Scale Your Reach: Top 15 Programmatic Advertising Agencies for Large Brands in 2025

When big brands step into the world of programmatic advertising, the stakes rise. 

Budgets are heavy, audiences are vast, and the competition never takes a coffee break. 

And with programmatic now accounting for 90% of all US digital display ad spend, the pressure to get it right has never been greater.

That’s where the right partners make all the difference. 

In this article, we’ve done the heavy lifting for you. 

We’ve pulled together a hand-picked lineup of the top programmatic advertising agencies built for large brands. 

The kind of partners who can handle global campaigns, juggle multi-channel demands, and keep performance sharp without losing sight of brand vision.

Here’s what you’ll find inside:

• Agencies with proven track records working with household names
• Clear highlights of what makes each agency stand out
• Insights that help you decide who deserves your next big brief

Keep reading, your next powerhouse partner might be just a few lines away.

P.S. Want to go beyond programmatic? Our roundup of the Best Digital Marketing Agencies for Large Companies will show you who’s winning across the entire digital game.

TL;DR: Top Programmatic Advertising Agencies for Large Brands

1. Fieldtrip: A full-service marketing agency that specializes in programmatic advertising. They cover strategy, creative, media, and measurement for integrated campaigns that scale quickly. Services include UGC, influencer content, paid social, CTV, and media planning.

2. inBeat: A programmatic advertising agency known for pairing precise media buying with influencer-driven creative. They test and optimize at scale, and turn UGC into a high-performing content engine. Services also cover SEO, lead generation, paid media, and social campaigns.

3. Adcetera: A programmatic agency built on automated DSPs and real-time analytics for smarter bidding and dynamic creative. They scale campaigns from hyper-local to global with precision and track performance in real time.

4. Loud Mouth Media: A performance-driven PPC agency. They offer paid search, display, SEO, and creative. Recognized as a Google Premier Partner.

5. Blackhawk: A digital marketing agency that delivers programmatic campaigns with advanced targeting using IPs, mobile IDs, and company lists. They focus on driving traffic and conversions through dynamic creative and performance monitoring.

What is a Programmatic Advertising Agency?

A programmatic advertising agency specializes in planning, buying, and optimizing digital ad placements through automated platforms.

Instead of relying on manual negotiations or broad targeting, these agencies use real-time data and algorithms to purchase ad inventory to lock in spots that match your audience perfectly. 

These agencies manage the tech, the bidding, and the creative blend, so campaigns run smoother than you could imagine. This level of efficiency simply cannot happen through old-school buying. 

So, what does this actually mean for big players in the market? Let’s unpack the benefits:

Benefits of Hiring a Programmatic Advertising Agency for Big Brands

Here’s where the decision to hire a specialist pays off:

You Get Scale Without Losing Control

Running campaigns across dozens of markets and platforms in parallel is heavy lifting. Specialized agencies bring the tech stack and buying power to run those ad campaigns at a massive scale while still giving you visibility on every placement. You see where budgets flow, how audiences react, and what’s delivering returns. 

That transparency matters: studies show that demand-side platforms retain or lose about 64% of ad spend, meaning only 36 cents of every dollar reaches its intended audience. 

That balance of reach plus clarity is hard to achieve in-house. Agencies already sit inside the platforms, with teams trained to interpret the data instantly. For a global brand, that means campaigns can go wide without feeling chaotic.

You Turn Data Into an Advantage

Data can overwhelm even the strongest in-house team. A programmatic agency thrives on it, treating performance metrics, audience signals, and spend data as raw material to shape campaigns. They use trading desks, DSPs, and analytics layers that most brands never fully integrate on their own.

The payoff is tangible: compared to non-targeted ads, programmatic campaigns deliver a 200% boost in click-through performance, proving how powerful precise data application can be.

The difference is visible in how campaigns evolve. With an agency, you get ongoing ad tracking and adjustments that push spend toward winning channels and formats, while optimizing budget allocation and cutting waste. This constant feedback loop makes campaigns smarter with every hour they run and deepens customer engagement at scale.

You Spend Smarter Than Any Internal Team Could

Hiring an in-house team means recruiting traders, analysts, tech staff, and strategists, then paying salaries before a single ad runs. A programmatic agency already has those resources locked and tested. 

They spread the cost across clients, so you benefit from infrastructure without carrying the overhead. It’s no wonder that 88% of marketers entrust agencies with at least a portion of their programmatic ad purchases, because it simply makes financial and strategic sense. 

Agencies aggregate knowledge, technology, and market access that would take years (and millions) to build internally. This translates into campaigns that deliver stronger ad performance, minimize risks like ad fraud, and maximize ROI with optimized ad templates tailored for each channel.

The theory is solid, but the real story starts with the names that put it into practice.

And that brings us to the main section:

An In‑Depth Look at the Best Programmatic Ad Agencies for Large Enterprises

Ready to see who makes programmatic work for the world’s biggest brands?

Here’s the list:

1. Fieldtrip

Fieldtrip is a full-service marketing agency trusted by leading brands to deliver measurable impact in programmatic advertising. 

With recognized expertise across strategy, creative, media, and analytics, they design campaigns that scale and adapt in real time to market conditions.

By combining deep data intelligence with bold creative execution, Fieldtrip’s cross-disciplinary teams ensure every campaign is precise, relevant, and performance-driven. 

Partnering with them means your brand connects with your audiences at the moments that matter most, driving immediate results and long-term growth.

Fieldtrip begins every engagement with a strategic audit and growth roadmap, giving you a clear vision for brand expansion across digital and programmatic channels. 

Once aligned on strategy, their team designs brand systems, produces original content, and deploys programmatic video campaigns that drive performance where audiences stream.

Their service suite extends beyond programmatic into a complete brand ecosystem. 

From UGC and influencer content to paid social, CTV, and media planning, they ensure creative assets flow seamlessly across channels. This integrated approach makes your campaigns consistent, scalable, and audience-focused.

The results back up their expertise.

• Greenpark partnered with Fieldtrip to launch its app through TikTok UGC campaigns that cut CPI by 70%, boosted daily installs sixfold, and scaled spend by 300%. 
• Soylent leveraged 50+ niche creators through Fieldtrip to drive millions of impressions and hundreds of reusable creator assets. 
• Nordstrom reached over 3 million views in a single week with an influencer gifting campaign that produced more than 500 assets across TikTok and Instagram.

Industries: Consumer Packaged Goods, Fashion, Beauty, Technology, Wellness, Sports, Gaming, Food And Beverage, and B2B

Notable clients: OpenAI, New Balance, Hurom, Miro, Nestlé, Hello Fresh, 7-Eleven

Key services:

• Programmatic Media Buying
• Out-of-home Advertising
• Digital Marketing
• Paid Social Campaigns
• Search Advertising Solutions (e.g., SEM)
• Programmatic Display & Video Campaigns
• Connected TV (CTV) Advertising
• Influencer Media Placements
• Podcast Production
• Video Content Production
• Social Media Management

Reason to work with Fieldtrip: You get a top-tier programmatic advertising partner that delivers millions of impressions to scale your brand presence.

2. inBeat

inBeat stands out as a top programmatic advertising agency trusted by large brands. They make sure that every media dollar is stretched for maximum impact by designing campaigns that capture attention and maximize conversions.

With programmatic at the center, inBeat builds campaigns that balance precise audience targeting with performance-based creative. 

They make sure that every element is tested, refined, and scaled to ensure maximum impact. By combining rapid experimentation with continuous optimization, inBeat delivers messaging that captures attention and consistently converts.

For Unroll.me, inBeat used influencer and paid media with a $3M+ programmatic budget, and tested over 40 creative assets per month. The result was over 7 million installs across iOS and Android, showcasing their ability to unite creative execution with data-driven precision.

inBeat also shines in the field of influencer marketing.

By connecting brands with the top 2% of creators, they generate authentic engagement and measurable growth. If you’re scaling quickly or building long-term consistency, inBeat coordinates hundreds of creator partnerships seamlessly, turning UGC into a high-performing creative engine.

This dual strength (performance media and influencer-driven creative) gives brands an edge. Programmatic budgets are powered by content that resonates, ensuring campaigns scale without sacrificing authenticity.

The agency also extends support with TikTok and Instagram marketing, SEO and AEO, lead generation, user acquisition, and even OOH.

Industries: Food & Beverage, Beauty, Mobile App, CPG and DTC brands, Retail, eCommerce, Agencies, Fashion

Notable clients: Bluehouse Salmon, Got Milk?, New Balance, Deux par Deux, Linktree, Hopper, Nissan, Disney, Hurom

Key services:

• Programmatic Media Buying
• Digital Marketing Services
• ABM Campaigns
• Link-Building
• Email Marketing
• Paid Media
• Social Media Management
• UGC Creation
• TikTok and Instagram Marketing & Advertising
• Micro-Influencer and Nano-Influencer Marketing
• SEO Solutions
• Content Marketing Services
• Creative Content Production
• Brand Development
• Product Marketing
• Lead Generation
• Google Ads

Reason to work with inBeat: You gain access to a programmatic team that has managed $3M+ budgets, and delivered over 7M installs.

3. Adcetera

Adcetera uses automated demand-side platforms tied directly to real-time analytics. This gives your campaigns the ability to land at the exact moment and place they matter.

They run across display, mobile, and video with bidding and dynamic creative execution that trims waste while keeping viewability high.

Their geographic scaling goes from zip-level hyper-local targeting to worldwide rollouts without losing precision. 

That flexibility makes them equally effective for regional activations and massive brand campaigns.

Horizon Bank tapped Adcetera for a full brand refresh under the positioning “Beyond Ordinary Banking.” Over 10 months, the multi-channel rollout drove a 37.3% year-over-year lift in HELOC applications, a 10% bump in business loan customers, and 134 new CD deposits.

Industries: Healthcare, Finance, Consumer Packaged Goods (CPG), Education, B2B Technology

Notable clients: Horizon Bank, Zebra Technologies, Mellow, Fracht Group

Key services:

• Programmatic media buying via DSPs and real‑time bidding
• Audience segmentation and strategy development
• Format‑specific campaign setup (display, video, mobile, native)
• Dynamic creative tailored to placements and devices
• Conversion tracking, analytics, and real‑time performance reporting
• Ongoing bid optimization and refinement

Reason to work with Adcetera: You get hyper-local to global programmatic reach with automated bidding that cuts spend waste while lifting viewability.

4. Loud Mouth Media

Loud Mouth Media runs PPC campaigns that scale across Search, Shopping, Display, YouTube, and Performance Max with precision. 

Their method is multi-platform, utilizing paid search, Display, video, performance creative, SEO, and more as one strategy that is designed to maximize channel impact.

They’re a Google Premier Partner, ranking among the top 3% of UK agencies, where their focus on conversion tactics is supported by solid data analysis.

For SSE Airtricity, they delivered a comprehensive SEO strategy of technical fixes, content optimization, and in-house training to strengthen visibility. The results included a 15% increase in organic clicks year-over-year, 13% growth in conversions, and a 7% uplift in Google SERPs clicks.

Industries: Automotive, Telecom & Utilities, Retail & eCommerce, Home Improvements, Technology & B2B Services

Notable clients: Lyle & Scott, Harry Corry Interiors, Lyle & Scott, GT Omega

Key services:

• Paid Search (Search, Shopping, Display, YouTube)
• Performance Max & Automated Bidding Strategies
• Microsoft Bing Advertising
• Conversion-driven Campaign Structuring and Real-time Optimisation
• Integrated Digital Strategy across Paid Social, SEO & Performance Creative

Reason to work with Loud Mouth Media: You get a Google Premier Partner in the top 3% of UK agencies delivering proven multi-channel campaigns with results like 5x ROAS and triple-digit conversion increases.

5. Blackhawk

Blackhawk Digital Marketing, based in Austin, runs programmatic campaigns that connect leads across display, mobile, and other formats. 

They rely on precise targeting built from IP addresses, mobile IDs, emails, and company lists, then match it with dynamic creative and conversion-driven copy to drive quality traffic and a stronger brand presence.

For SmileRight Kids Dentistry, the impact was immediate. 

Website users doubled in the first month, while six months of Facebook ads produced 1.5 million impressions and accounted for half of all site visits. 

The campaign turned a new pediatric dental practice into a digitally visible and appointment-ready business almost instantly.

Industries: Restaurants, Plumbing, Travel & Hospitality, Medical, CPG, HVAC, Real Estate, Health & Wellness, Landscaping, Electrical, Financial Services, Education, Construction, Pest control, Moving & Storage, Energy

Notable clients: SmileRight Kids Dentistry, Keeping Austin Beautiful, BTX, Skyco, Texas Sun & Shade

Key services:

• Programmatic ad campaign strategy and execution across varied display formats
• Utilization of advanced targeting parameters: IPs, mobile IDs, email and company lists
• Experience with campaigns for both B2B and B2C audiences
• Real-time monitoring of ad spend, impressions, clicks, and conversions
• Monthly performance reviews and agile adjustments

Reason to work with Blackhawk: You gain a trusted partner that delivers results like doubling site users in a month and generating 1.5 million ad impressions in six months.

6. Soap Media

Soap Media mixes real-time bidding with cross-device touchpoints to deliver display ads that actually meet users where they are, regardless of screen or mindset. 

Their work spans programmatic display, PPC, SEO, digital PR, email, analytics, and web design, stitched together into one coordinated digital play.

They gain access to the Google Display Network, which hits over 90% of internet users. That level of reach supports both high-volume brand plays and precise audience targeting.

For YorkTest, Soap Media planned ahead by auditing before December to capitalize on January spikes, then scaled budgets mid-January while tracking KPIs in real time with a custom dashboard. 

The result was a 20% increase in UK PPC revenue with stable CPA and ROAS, and in the US, a 63% PPC revenue jump and an 8% ROAS lift within the first half of the partnership.

Industries: Arts & Tourism, B2B, eCommerce, Education, Financial Services, Home & Garden, Hospitality, Legal Services, Medical, People & Relationships, Property & Construction, Public Sector, Recruitment, Social, Social Care, Voluntary & Third Sector

Notable clients: YorkTest, Claremont, Jacuzzi, Ideal4Finance

Key services:

• Deep-dive audit and definition of campaign objectives
• Persona-based audience segmentation and journey mapping
• Real-time bidding combined with dynamic, cross-device retargeting
• Creation of cohesive, attention-grabbing ad creatives
• Continuous campaign optimization and transparent reporting

Reason to work with Soap Media: You get a team that blends reach and precision, proven by delivering a 63% PPC revenue increase and 8% ROAS lift.

7. Adspace

Adspace® uses display, native, and video creatives alongside AI-driven real-time bidding to target audiences across mobile, desktop, and social platforms.

Their track record includes over $250 million in ad revenue across 247 projects, proving consistency at scale.

They run as a full-service performance shop, covering programmatic and paid campaigns across Facebook, Google, TikTok, YouTube, CTV, LinkedIn, Pinterest, and Twitter. 

On top of that, they deliver creative production, influencer strategy, web design, and analytics that tie acquisition directly to conversions.

For Ana Luisa, Adspace® started with a detailed brand audit to refine targeting and messaging, then executed a full-funnel plan across paid search, social, influencer, and email. 

The campaign cut customer acquisition cost by 29%, raised ROAS by 122%, increased affiliate revenue by 24%, and lifted customer lifetime value by 17%.

Industries: Wellness, Food & Beverage, Outdoor, DTC, Jewelry, Retail, eCommerce

Notable clients: Ana Luisa, Camelbak, Daily Stoic, Whole30

Key services:

• Programmatic display, video, and native ad strategy and execution
• Advanced targeting (demographic, behavioral, contextual, geographic)
• Real-time data analytics
• Transparent performance reporting and analytics
• Scalable campaign design, from small pilots to national rollouts
• Creative development including dynamic creative optimization (DCO) and A/B testing

Reason to work with Adspace: You get a partner experienced in scaling brands with full-funnel strategies that lower acquisition costs, increase return on ad spend, and drive long-term customer growth.

8. M+C Saatchi Performance

M+C Saatchi Performance builds programmatic campaigns that balance brand visibility with performance results, running across display, video, connected TV, audio, and DOOH with tech-agnostic bidding. 

Their footprint stretches across Singapore, Jakarta, London, New York, Los Angeles, Bangalore, New Delhi, Sydney, Bangkok, and Dubai, giving them global reach with local expertise.

Whether you want a fully outsourced model or in-house capability, they support everything from DSP selection to integrating with 30+ vendors, shaping programmatic strategies to fit internal structures.

The AlloFresh “S3 Belanja” campaign in Indonesia shows the model in action. 

By centering moms with messaging around simplicity, affordability, and completeness, the initiative delivered a 13% rise in brand awareness, doubled first-time transaction volumes, and cut CAC by 40%, marking a new low for the client. 

The phased media rollout, spanning paid social, programmatic, influencer, video, and CTV, added storytelling through creator Tasya Kamila while locking in business results.

Industries: eCommerce, Mobile, Entertainment, Retail, Tech, B2B, Food & Beverage

Notable clients: AlloFresh, Amazon, SEGA, Rakuten

Key services:

• Programmatic media buying across display, video, CTV, audio, and DOOH
• Data-led audience targeting and market insights
• Campaign management, optimization, and operations
• Holistic measurement and reporting aligned to KPIs
• Brand safety protocols and technical integrations
• Consulting and bespoke in-house support
• Web development

Reason to work with M+C Saatchi Performance: You get global programmatic expertise paired with proof of doubling first-time transactions and driving CAC down 40% in a single campaign.

9. Cyberclick

Cyberclick combines programmatic precision with native integration. They run campaigns through advanced real-time bidding across video, display, audio, and emerging platforms like Spotify and connected TV outlets such as Rakuten, Samsung, and Amazon Prime Video.  

They also partner with major media groups including Mediaset, A3Media, TV3, and DAZN to extend reach across premium inventory.

Their proprietary Feedest tech powers personalized remarketing with strong visuals that keep brands top-of-mind while driving conversions. 

For skincare brand MiiN, Cyberclick delivered a TikTok campaign that raised ROAS by 25.7%, reduced cost per add-to-cart by 11.8%, and cut cost per acquisition by 5.8%. The strategy combined traffic generation and remarketing, using TikTok Catalog, Spark, and Lead Generation formats to re-engage leads and convert them efficiently.

Industries: Retail, Automotive, Technology, Entertainment, Beauty, Professional Services, Travel & Tourism

Notable clients: MiiN, Pioneer, Hero, Repavar

Key services:

• Programmatic media buying via real-time bidding systems
• Native ad creation and strategic integration for seamless engagement
• Multi-channel placements including Twitch, Amazon Prime Video, Spotify, connected TV, and major media groups
• cyberclick.net
• High-impact, personalized remarketing supported by proprietary tech like Feedest
• Real‑time dashboards, custom metrics, and enriched analytics via Amazon Marketing Cloud

Reason to work with Cyberclick: You get a programmatic partner with proprietary tech delivering results like 25.7% higher ROAS and lower acquisition costs across new channels like TikTok and connected TV.

10. PrograMetrix

PrograMetrix uses advanced ad-tech alongside a human-driven approach to run omnichannel campaigns across display, mobile, CTV/OTT, audio, retail media, DOOH, native, video, paid social, and paid search. 

Their audience-first strategy starts with a detailed TAM definition, 1P data onboarding, and retail shopper data from Amazon, Walmart, Target, and Kroger to refine targeting.

They deliver reach across platforms like Netflix, Hulu, Disney+, YouTube TV, Spotify, Pandora, and satellite radio, ensuring you relevance and quality placements.

Their work with Money20/20 shows the model in practice. 

By combining streaming audio, video, search retargeting, and A/B audience testing, they secured renewed and expanded media budgets for the U.S. and Europe while setting up entry into APAC. The U.S. campaign drove 1,241 ticket purchases at $47 each, delivering 47x ROAS, while in Europe they added 189 purchases, lifted the conversion rate by 355%, and produced 2.8x ROAS.

Industries: B2B brands, Retail & eCommerce, Advertising agencies

Notable clients: Money20/20, PayPal, Edmunds, Computershare

Key services:

• Media Planning & Buying
• Email Marketing
• Video Advertising
• Campaign Management
• Data Analytics
• Ad Tech Integration
• Performance Optimization
• Reporting & Measurement

Reason to work with PrograMetrix: You get omnichannel campaigns that deliver numbers like 47x ROAS in the U.S. and a 355% conversion rate lift in Europe.

11. Pathlabs

Pathlabs works as a full-service white-label Media Execution Partner, taking on planning, activation, optimization, and transparent reporting so agencies can focus fully on strategy.

With $200M+ in managed media spend, they’ve built operations at a scale that rivals the biggest players.

Each account is supported by a dedicated seven-person team covering ad ops, analytics, account management, and more. 

That structure ensures depth in execution and accountability across every channel.

Their partnerships with DSPs like The Trade Desk, DV360, and Amazon DSP anchor campaigns that total more than $165 million in digital media every year. 

The agency puts relationships at the center of everything: partners, employees, managers, and peers alike. 

This is reflected in client feedback:

“Life without Pathlabs is hard to imagine. They’re incredibly passionate, caring, empathetic, and supportive human beings who see the bigger picture and are committed to our growth. And that’s partnership.”

Industries: Agencies, Retail, Professional Services, B2B

Notable clients: Cayenne Creative, CCF, Simantel

Key services:

• Full-service programmatic media execution including ad serving, targeting, optimization, and reporting
• Media Execution Partnership (MEP)
• Access to an integrated ecosystem of platforms and tools (e.g. Amazon, Google, TikTok, The Trade Desk, and more)
• Data-driven insights, attribution, and business-aligned performance tracking
• Custom reporting and real-time dashboards

Reason to work with Pathlabs: You get a $200M+ media execution partner assigning a seven-person team per account and managing $165M annually through top DSPs.

12. Uplers

Uplers runs as a programmatic talent platform, and gives clients access to pre-vetted, AI-screened experts within 48 hours. 

Their specialists bring hands-on experience managing quarterly budgets ranging from $1.3-2 million across DV360, The Trade Desk, and CM360, making them a strong fit for SaaS and high-growth verticals.

Every hire comes with lifetime free replacement and support across multiple time zones, giving clients both dependability and global coverage.

Uplers also stands out for scale and credibility, with 1.5 million LinkedIn followers and ratings of 4.9/5 on Clutch and 4.1/5 on Google. 

Industries: SaaS, B2B, Tech

Notable clients: LemonEdge, Twilio, Tripadvisor

Key services:

• Rapid sourcing of top third‑to‑fifth‑percentile programmatic talent (within 48 hours)
• AI‑assisted and human‑verified vetting process
• Talent support across the full programmatic lifecycle: strategy, planning, execution, optimization, reporting
• Specialized campaign support (e.g. webinars, gated content, virtual events)
• Strong alignment with B2B/SaaS funnel metrics (MQLs, SQLs, conversions)

Reason to work with Uplers: You get programmatic talent in 48 hours with proven $2M quarterly budget experience, backed by lifetime free replacement and global support.

13. 23 Digital

23 Digital runs programmatic campaigns with end-to-end coverage, from strategy and media planning through creative, data analysis, and real-time optimization. 

Their setup connects programmatic with web, eCommerce, PPC, and SEO, creating seamless execution supported by transparent ROAS-focused reporting.

They operate as a true full-service partner. For Vital Proteins, 23 Digital delivered a digital transformation. 

They launched a Shopify Plus build with full NetSuite integration to support both B2C and B2B growth across APAC. The results included a 9x increase in monthly sales within six months, a 42% uplift in conversion rates and 250+ wholesale accounts onboarded.

Industries: Accessories, Apparel, B2B Supplies, Cleaning & Hygiene, Ecommerce, Education & Recruitment, Equipment Supplies, Fashion, Finance, Fitness, Food & Beverages, Furniture, Healthcare, and others

Notable clients: Tigerpak, Brooks, SiS

Key services:

• Strategy development and campaign planning tailored for programmatic media
• Media planning and buying via automated platforms (DSP, SSP, ad servers, and verification tools)
• Creative development tuned to campaign goals and platform formats
• Audience profiling leveraging demographics, interests, behaviors, and context
• Real-time data analytics

Reason to work with 23 Digital: You get a partner that engineered 1,000% sales growth and 800% organic traffic gains through full-service digital transformation.

14. Huble

Huble runs programmatic campaigns by combining algorithmic automation with strategic oversight, designed to raise revenue while lowering costs through smarter planning, buying, and optimization. 

With 175+ employees, 7 offices worldwide, and 11 years of execution, they bring the structure and scale needed for complex programmatic operations.

What stands out: their “Seek Evolution” ethos, which frames constant optimization as a core operating principle across every campaign.

For a communications solutions provider, Huble shifted event marketing budgets into digital campaigns across Google Ads, LinkedIn Ads, and Facebook Ads. Across three years, they executed more than 300 campaigns, delivered 4,000 leads, and cut Google Ads cost per conversion by 75%.

Industries: Media, Government, eCommerce, Education, Financial Services, Professional Services, IT & Communications, Manufacturing & Engineering, Travel & Leisure, Healthcare, SaaS, Real Estate

Notable clients: Zivver, AirPlus, Mitie

Key services:

• Programmatic strategy, planning, and creative execution
• Intelligent audience segmentation and data-driven targeting
• Managed media buying via strategic DSP partnerships
• End-to-end campaign optimization and performance monitoring
• PPC advertising

Reason to work with Huble: You gain a partner with 11 years of experience that has delivered 4,000 leads and reduced cost per conversion by 75% through programmatic reinvention.

15. Go Fish Digital

Go Fish Digital drives programmatic campaigns with advanced algorithms and real-time bidding designed to maximize ROI and scale awareness across channels. 

Their team covers the full-service spectrum, from platform selection and automated buying to data-driven targeting and transparent monthly reporting.

Their capabilities extend across the funnel, combining audience discovery with prospecting and retargeting strategies through DSPs like DV360 and The Trade Desk. This ensures that campaign performance is steady from first touch to conversion.

For GetResponse, Go Fish Digital created a digital PR campaign built around a survey on the most annoying business jargon. 

The campaign drove 13 high-authority backlinks, attracted 8,000+ new sessions, and contributed to a 60% year-over-year increase in organic traffic.

Industries: eCommerce, Consumer Services, Technology, Real Estate & Hospitality, Education, Government & Non-Profit, Professional Services

Notable clients: Joybird, Cailini Coastal, BetterUp

Key services:

• Programmatic platform selection, tailored to campaign goals
• Data-driven audience targeting using demographics, interests, and behavioral signals
• Automated media buying powered by real‑time bidding (RTB)
• Hyper‑targeted display strategies spanning prospecting to dynamic retargeting (via DV360, The Trade Desk)
• Transparent custom reporting, delivered monthly
• Video advertising

Reason to work with Go Fish Digital: You get a full-funnel partner that delivered a 95% revenue lift and 40% ROAS jump using Performance Max campaigns.

Top Considerations for Selecting a Programmatic Advertising Partner

Before the handshake, make sure they can actually hold the weight of your campaigns.

Scrutinize Their Access to Premium Inventory

Inventory access defines reach and quality. Without relationships on private marketplaces and premium publishers, agencies rely on leftovers. That shows up in performance through weaker placements and audience fatigue. 

In 2024, private marketplaces captured 59% of programmatic spend (vs. 41% in 2023), underscoring how advertisers increasingly prioritize premium, controlled inventory.

Ask which private marketplace deals they hold. Look for partnerships with top-tier publishers and video platforms. If they only mention open exchanges, it signals limited reach and recycled audiences.

Verify Their Compliance and Brand Safety Standards

At enterprise scale, one bad placement can turn into a PR disaster. Agencies that take shortcuts expose your brand to unsafe sites, bot traffic, or data privacy violations. 

The risk is not hypothetical: programmatic advertising is notoriously vulnerable, with fraud rates estimated as high as 50%. That means the damage extends far beyond wasted spend, encompassing brand reputation and even regulatory exposure. 

Ask what systems they use to protect campaigns. Look for third-party verification, fraud detection tools, and clear brand safety policies. If they wave it off with “our platforms handle it,” that’s a warning sign.

Push Them on Talent Depth Beyond Just Tools

Anyone can claim access to premium platforms, but without experienced traders and analysts, those tools deliver average results. The quality of people running the desk decides whether your brand gains an edge or just burns budget at scale. 

In fact, the challenge is industry-wide: 20% of advertisers in IAB Europe’s 2024 Attitudes to Programmatic study cited hiring and training talent as the top barrier to growth.

Ask who will actually manage your account. Look for credentials, years of trading experience, and proof they’ve worked campaigns of similar complexity. If the team is junior-heavy with one senior figurehead for show, that’s a red flag.

Wrapping Up

You’ve just seen the top programmatic agencies built to serve large enterprises. This list gives you the players who know how to manage serious budgets and deliver at scale.

Hiring one of these agencies means sharper campaigns, higher returns, and fewer wasted dollars. You get stronger audience connections, campaigns that adjust in real time, and results that move the needle on revenue instead of vanity metrics.

If you want a recommendation, start with Fieldtrip or inBeat. Both bring proven expertise, strong teams, and a track record of winning big campaigns for global brands. They’re the kind of partners that actually make your investment work harder.

At this point, the decision is yours. Choose the agency that fits your goals and budget, and trust that you now have a shortlist built for smarter choices. The right partner is waiting to help you push your campaigns further and hit outcomes that matter.

P.S. Want to expand beyond digital placements? Our guide to the Top Connected TV Advertising Agencies for Enterprises shows who’s winning on the big screen.

Frequently Asked Questions

How much does programmatic advertising cost?

Programmatic ad costs usually sit around $0.50 to $5 per thousand impressions (CPM), depending on ad format, targeting precision, and market demand. Video or competitive audience segments push CPMs toward the higher end. Pricing models shift too: CPM, CPC, and CPA each shape spend in different ways.

Why should you hire a programmatic advertising agency for your business?

Hiring a programmatic agency gives you expertise, technology, and buying power that are hard to build in-house. They manage campaigns in real time, shifting spend to what actually drives performance. Agencies bring relationships with platforms and publishers that give your brand stronger placements. You also get access to advanced reporting and analysis without having to build your own stack.

Are programmatic advertising agencies worth it?

Yes, when your brand runs campaigns at scale, programmatic agencies more than pay for themselves. They cut wasted ad spend by ensuring every impression hits a relevant audience. Their teams handle campaign design, targeting, bidding, and optimization with a level of depth most brands can’t match. The result is more sales, stronger brand visibility, and measurable returns on every dollar spent.

What’s the difference between a generalist agency and an enterprise-focused programmatic advertising agency?

A generalist agency offers a mix of services across digital channels, often spreading resources thin. An enterprise-focused programmatic agency specializes in large-scale media buying, working with advanced platforms and global budgets. They know how to manage compliance, creative rotations, and multi-market campaigns simultaneously.

How do I choose the best programmatic advertising agency?

Focus on agencies with real access to premium inventory, strong compliance standards, and a team of seasoned traders. Ask about their private marketplace deals, brand safety systems, and the actual staff who will run your campaigns. Look for proof of relationships with top publishers, third-party verification tools, and talent with enterprise-level experience.